Emerging Trends of Nanotechnology towards Picotechnology: Energy and Biomolecules

In nature, metal oxide particles display their existance of picomolecules in solution state at the picoscale and bioactive states in the body. We put evidence of picomolar behavior of picoscale molecules different than nanomolar behavior of particles using PICOTECHNOLOGY devices. PICOTECHNOLOGY means picomolar measurement of picoscale molecule physical properties measured by pico-devices or picoscopes. The picoscale particles can be encapsulated more precisely within polymers and can be functionalized with protein, nucleotides, and drugs at picoscale to develop as smart intracellular targeting/ monitoring pico-carrier devices. The preparation technique and physiological conditions at picoscale decide the size and functionality of these pico-carrier devices. Their usable success rate, feasibility and potentials are yet to be proven or we donot know. The major difference between nanodevices and pico-devices is their intermolecular and intramolecular thermodynamics in medium and their molecular conformational interaction with molecular assembly in cytoarchitecture of the neurofilament, actin-myosin, microtubule proteins. In future, picoscale-carrier device can be presumed as potential spears without interacting with host signal transduction and immunoprotection. Present time, picoscopes, picoscale physical instruments are in use for monitoring purposes. In conclusion, ultrafine size of newer picotechnology products may be better suited and easy to functionalize them for design of particle based picodrug, picochemicals, pico-targeting molecules.